The studies on platelets for determining “growth factor” started back in 1990’s, but there was no proper exposure. A substantial research was done for the first time in 2005 by Carlos Uebel, who for the first time used platelet concentrate in hair restoration. The result highlighted an increased yield when the platelets were applied as a graft storage medium.
In 2007 a major breakthrough took place when Joseph Greco expanded the use of Platelet Rich Plasma in hair restoration surgery to improve the donor site wound healing. This observation being anecdotal required a proper study to establish that the plasma components which is platelet rich had any effect on non-transplanted hair or not.
Fortunately, in 2009, Greco and Brant received a grant to carry out the study and determined that Platelet Rich Plasma Therapy (PRP) had “growth factors” and can certainly turn on the dormant follicular stem cells caused by Alopecia Areata (the inflammatory cytokines) around 60%.